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Subthreshold micropulse laser for subretinal fluid after vitrectomy in myopic traction maculopathy: a pilot
Xifang Zhang1, Haixia Ji1, Zhaoyang Wang1
1Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Tongren Hospital, Beijing, China.
Lasers in Medical Science
|June 29, 2026
Summary
Subthreshold micropulse laser (MPL) is safe for treating residual subretinal fluid (SRF) after vitrectomy in myopic traction maculopathy. While MPL showed a trend toward better SRF absorption, results were not statistically significant, suggesting potential RPE compromise in highly myopic eyes.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Surgical Innovation
Background:
- Myopic traction maculopathy (MTM) can leave residual subretinal fluid (SRF) after vitrectomy.
- Evaluating new treatments for persistent SRF is crucial for improving outcomes in MTM patients.
Purpose of the Study:
- To assess the safety and efficacy of subthreshold micropulse laser (MPL) for residual SRF after vitrectomy in MTM.
- To compare SRF absorption rates between MPL treatment and standard care.
Main Methods:
- Prospective, pilot randomized controlled trial involving 40 patients with MTM and residual SRF (≥200 μm).
- Patients were randomized 1:1 to a control group or MPL treatment group.
- MPL was administered 1 month post-surgery, with potential repeat treatments; follow-up was at least 6 months.
Main Results:
- Both groups showed significant improvement in best-corrected visual acuity (BCVA) and reduced macular thickness postoperatively.
- The MPL group received an average of 2.05 MPL sessions.
- A trend towards better SRF absorption in the MPL group was observed, but the difference was not statistically significant (P=0.33).
- No severe complications were reported in either group.
Conclusions:
- Subthreshold micropulse laser (MPL) is a safe, non-invasive option for patients with pathologic myopia and residual SRF.
- The limited impact of MPL on SRF absorption may be due to compromised retinal pigment epithelium (RPE) function in highly myopic eyes.
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