Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Imaging Biological Samples with Optical Microscopy

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...

Overview of Microscopy Techniques

Overview of Microscopy Techniques

The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Does introducing an immunization package of services for migrant children improve the coverage, service quality and understanding? An evidence from an intervention study among 1548 migrant children in eastern China.

BMC public health·2015

Same author

[Dynamic and quantitative analysis of cariogenic bacteria and its proportion in the dental plaque of different caries-susceptible children].

Shanghai kou qiang yi xue = Shanghai journal of stomatology·2015

Same author

Prevalence and influencing factors of co-morbid depression in patients with type 2 diabetes mellitus: a General Hospital based study.

Diabetology & metabolic syndrome·2015

Same author

Paraventricular Nucleus Infusion of Epigallocatechin-3-O-Gallate Improves Renovascular Hypertension.

Cardiovascular toxicology·2015

Same author

Enhancement of the thermostability of Streptomyces kathirae SC-1 tyrosinase by rational design and empirical mutation.

Enzyme and microbial technology·2015

Same author

The dynamics of hypertension prevalence, awareness, treatment, control and associated factors in Chinese adults: results from CHNS 1991-2011.

Journal of hypertension·2015

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Published on: August 4, 2018

Real-World Application of Microscope-Integrated 400 kHz Swept-Source Intraoperative OCT in Ophthalmic Surgery.

Xifang Zhang¹, Shuang Liu², Jing Guo¹

¹Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Alley, Dongcheng District, Beijing 100730, China.

Journal of Clinical Medicine

|June 26, 2026

Summary

The 400 kHz swept-source intraoperative optical coherence tomography (SS-iOCT) system demonstrated feasibility and clinical utility in various ophthalmic surgeries. This technology enhances surgical precision and real-time decision-making for improved patient outcomes.

Keywords:

choroidal melanoma intraocular tumors intraoperative OCT ophthalmic surgery swept-source OCT

More Related Videos

Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation

Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation

Published on: January 22, 2013

Related Experiment Videos

Last Updated: Jun 27, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Published on: August 4, 2018

Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation

Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation

Published on: January 22, 2013

Area of Science:

Ophthalmology
Surgical Technology
Medical Imaging

Background:

The integration of advanced imaging technologies into ophthalmic surgery is crucial for enhancing visualization and decision-making.
Swept-source optical coherence tomography (SS-iOCT) offers high resolution and penetration depth, making it a promising tool for intraoperative guidance.

Purpose of the Study:

To evaluate the feasibility and clinical utility of a 4K ultra-HD microscope integrated with a 400 kHz SS-iOCT system in diverse ophthalmic surgical procedures.
To assess the impact of SS-iOCT on surgical decision-making and technique modification in a real-world clinical setting.

Main Methods:

A descriptive analysis of 72 consecutive ophthalmic surgeries utilizing the SS-iOCT system was performed.
Cases were selected based on SS-iOCT providing critical, real-time information that directly influenced surgical management.

Main Results:

The SS-iOCT system was applied across a spectrum of conditions including macular holes, retinal detachments, submacular hemorrhage, and intraocular mass lesions.
The 400 kHz SS-iOCT system significantly improved surgical visualization, guided real-time decision-making, and prompted necessary modifications in surgical techniques.

Conclusions:

This study represents the first real-world evaluation of a 400 kHz SS-iOCT system across a wide range of ophthalmic conditions, including novel applications in intraocular tumors.
The SS-iOCT system enhances surgical precision and facilitates real-time decision-making, contributing to improved outcomes in both routine and complex ophthalmic surgeries.