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Effects of suprapubic photobiostimulation on bladder function in two girls with Hinman syndrome

Maria Verônica Pires1,2, Jorge Nilton Casotti3, Henrique Cunha Carvalho4

  • 1Biomedical Engineering Institute, Anhembi Morumbi University, São Paulo, Brazil. mariaveronicapires46@gmail.com.

Lasers in Medical Science
|August 12, 2026
PubMed

Insights

Photobiostimulation (PBST) therapy improved bladder emptying in children with Hinman syndrome (HS). This non-invasive treatment reduced post-void residual urine and enhanced voiding efficiency in pediatric patients.

Area of Science:

  • Pediatric Urology
  • Bioengineering
  • Clinical Therapeutics

Background:

  • Hinman syndrome (HS) is a severe form of dysfunctional voiding in children, presenting as functional bladder outlet obstruction without neurological deficits.
  • Patients with HS often exhibit detrusor hypocontractility and reduced bladder emptying efficiency.

Purpose of the Study:

  • To evaluate the efficacy of photobiostimulation (PBST) as a therapeutic intervention for pediatric patients diagnosed with Hinman syndrome.
  • To assess the impact of PBST on urodynamic parameters, specifically bladder emptying and voiding efficiency.

Main Methods:

  • Two pediatric patients with HS received PBST using red spectrum (630 nm) light-emitting diodes (LEDs) applied to the suprapubic region.
  • Baseline urodynamic assessments (cystometry, pressure-flow studies) were followed by serial uroflowmetry during treatment to monitor bladder emptying parameters.

Main Results:

  • Following PBST, significant reductions in post-void residual (PVR) were observed: 93.6% in patient 1 and 59.6% in patient 2.
  • Voiding efficiency (VE) increased substantially: 277.4% in patient 1 and 18.7% in patient 2, indicating improved bladder emptying.
  • Improvements in detrusor kinetic parameters were also noted, suggesting enhanced bladder contractility.

Conclusions:

  • Preliminary findings suggest PBST may be a beneficial non-invasive adjunctive therapy for improving bladder emptying in pediatric patients with dysfunctional voiding, such as HS.
  • The observed functional improvements are biologically plausible due to the known bioenergetic effects of PBST.
  • Further research is warranted to confirm the efficacy and optimal application of suprapubic PBST for pediatric dysfunctional voiding.

Keywords:
Dysfunctional voidingHinman syndromePhotobiostimulationUrodynamics

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