Purine Scaffold in Agents for Cancer Treatment.

Area of Science:

• Medicinal Chemistry
• Supramolecular Chemistry
• Pharmacology

Background:

• Cancer remains a significant global health threat.
• Purine derivatives are known for diverse pharmacological effects.
• The purine scaffold is a key motif in potent anticancer agents.

Purpose of the Study:

• To review recently designed anticancer agents featuring the purine scaffold.
• To analyze structure-activity relationships and identify promising compounds.
• To explore advanced strategies like metal coordination and nanoassembly for enhanced efficacy.

Main Methods:

• Literature review of articles published in 2023-2024.
• Analysis of structure-activity relationships (SAR) of purine derivatives.
• Evaluation of metal coordination, conjugation, and nanoassembly approaches.

Main Results:

• Identified purine-based compounds with high cytotoxicity and favorable physicochemical properties.
• Demonstrated advantages of metal ion coordination, conjugate formation, and nanoassemblies over parent compounds.
• Highlighted the impact of scaffold substituents on cytotoxic effects.

Conclusions:

• The purine scaffold is crucial for developing novel anticancer therapeutics.
• Advanced strategies significantly enhance the biological activity and characteristics of purine-based agents.
• Interdisciplinary research in medicinal, supramolecular chemistry, and pharmacology is vital for future drug discovery.