Humoral SARS-CoV-2 vaccine responses are durable in solid organ transplant recipients with and without HIV

Solid organ transplant (SOT) recipients may have a suboptimal humoral immune response to the coronavirus disease 2019 (COVID-19) vaccine, prompting the need for additional doses of vaccine for immunocompromised patients. However, data regarding immune responses to vaccination specifically in SOT recipients with well controlled HIV are lacking.

We conducted a prospective observational cohort single-center study of SOT recipients with and without HIV-1 who had received two doses of mRNA COVID-19 vaccine and were planning to receive additional doses. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binding and neutralizing antibody responses were measured at several time points after vaccination.

Of the 122 SOT recipients enrolled, 44 (36%) were people with HIV (PWH). Overall, 65% (50/77) of all SOT recipients were seropositive prior to a third vaccine dose. Seropositive SOT recipients with HIV had comparable anti-spike antibody responses at baseline and over time to those without HIV. In addition, HIV status did not impact neutralizing titers in our SOT cohort. Twenty-seven participants were seronegative at baseline; three (11%) were participants with HIV. In addition, 78% (21/27) of participants seroconverted over the duration of the study; of those who remained seronegative, none had HIV, but all were on an antimetabolites.

HIV status did not impact longitudinal spike-binding antibody titers or neutralizing titers in SOT recipients.