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Nomogram for Predicting Sepsis After Percutaneous Transhepatic Cholangioscopic Lithotripsy
Lve Cheng1, Xiong Ding1, Jie Liu1
1Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Journal of Inflammation Research
|May 19, 2025
Summary
Sepsis is a risk after percutaneous transhepatic cholangioscopic lithotripsy (PTCSL). This study identified operation technique, cirrhosis, and dexamethasone as predictors, developing a nomogram to assess sepsis risk in patients undergoing PTCSL.
Area of Science:
- Hepatology
- Gastroenterology
- Infectious Diseases
Background:
- Sepsis is a serious complication of percutaneous transhepatic cholangioscopic lithotripsy (PTCSL) for hepatolithiasis.
- Currently, risk assessment tools for predicting sepsis post-PTCSL are lacking.
Purpose of the Study:
- To identify predictors of sepsis following PTCSL.
- To develop a predictive nomogram for sepsis complications after PTCSL.
Main Methods:
- A nested case-control study reviewed data from 528 PTCSL sessions.
- Least Absolute Shrinkage and Selection Operator (LASSO) and multivariable logistic regression were used to identify sepsis predictors.
- A predictive nomogram was constructed and validated.
Main Results:
- The incidence of sepsis post-PTCSL was 10.69%.
- Key predictors identified were operation technique, cirrhosis, and postoperative prophylactic dexamethasone.
- The nomogram demonstrated good discriminative ability (AUC 0.756-0.762) and clinical utility.
Conclusions:
- Operation technique, cirrhosis, and postoperative dexamethasone are significant predictors of sepsis after PTCSL.
- The developed nomogram is a valuable tool for predicting sepsis complications, aiding clinical decision-making.
