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Updated: Jun 12, 2025

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
A protocol for selective synthesis of thiol-functionalized allylic sulfonyl fluorides
Monday Peter Ajisafe1,2, Heba H Mohamedy1, Eman Fayad3
1School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, China. qinhuali@whut.edu.cn.
None:
An efficient and transition metal-free method has been established for synthesizing a class of novel thiol-functionalized allylic sulfonyl fluorides with exclusive regioselectivity. This method is distinguished by its broad functional group compatibility with up to 99% yield and mild reaction conditions. Additionally, subsequent SuFEx reactions and oxidation processes generated sulfonate, sulfoxide, and sulfone derivatives, which are key motifs in medicinal chemistry, with exceptional efficiency.
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