S100A12 Protein Levels in Juvenile Idiopathic Arthritis (JIA): a Systematic Review and Meta-Analysis
Clinical Laboratory
|May 19, 2025
Summary
Serum S100A12 protein levels are significantly elevated in children with juvenile idiopathic arthritis (JIA) compared to healthy individuals. This finding suggests S100A12 may serve as a potential biomarker for diagnosing JIA.
Area of Science:
- Biochemistry
- Immunology
- Pediatrics
Background:
- Juvenile idiopathic arthritis (JIA) is a significant cause of childhood disability.
- Previous studies show inconsistent associations between S100A12 protein levels and JIA.
- Further investigation is needed to clarify the role of S100A12 in JIA.
Purpose of the Study:
- To systematically review and meta-analyze the association between S100A12 protein levels and JIA.
- To assess the diagnostic potential of S100A12 as a biomarker for JIA.
Main Methods:
- Systematic literature search of Embase, PubMed/Medline, Web of Science, and Scopus up to December 2022.
- Inclusion of 9 studies with 518 JIA patients and 345 healthy controls.
- Data analysis using R-4.4.0 software.
Main Results:
- Pooled analysis revealed significantly higher serum S100A12 protein levels in JIA patients versus healthy controls (SMD = 2.18).
- Subgroup analyses by geography (Europe, Asia) and study type (cohort, case-control) also showed significant increases in S100A12 levels.
- High heterogeneity was observed across subgroups, indicating variability in study findings.
Conclusions:
- Serum S100A12 protein concentrations are significantly elevated in JIA patients.
- S100A12 protein shows potential as a biomarker for juvenile idiopathic arthritis.
- Further research may refine the clinical utility of S100A12 in JIA diagnosis and management.
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