Framework to identify innovative sources of value creation from platform technologies.

Area of Science:

• Pharmaceutical Sciences
• Biotechnology
• Health Economics

Background:

• Platform technologies are revolutionizing pharmaceutical R&D and drug development.
• Existing valuation models, focused on single assets, inadequately assess platform technology value.
• A new approach is needed to capture the multifaceted value generated by these technologies.

Purpose of the Study:

• To present a comprehensive framework for evaluating the innovative value of platform technologies in pharmaceuticals.
• To develop a structured methodology for capturing diverse benefits across the drug development lifecycle.
• To inform strategic decision-making in R&D investment and portfolio management.

Main Methods:

• Systematic literature review.
• In-depth case studies of leading platform technologies.
• Development of the Platform Value Identification across Strategic, Technical, and Adaptive domains (PVISTA) Framework.

Main Results:

• Platform technologies create value across strategic, technical, and adaptive dimensions.
• The PVISTA framework defines key value drivers and quantitative assessment metrics.
• Case studies (Alnylam, Genentech, Moderna) demonstrate the framework's utility and impact potential.

Conclusions:

• A multifaceted, data-driven valuation approach is essential for platform technologies.
• The PVISTA framework aids stakeholders in assessing long-term value and competitive advantages.
• Adoption of this framework can accelerate the development of transformative therapies.