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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Overview of Exosomes01:36

Overview of Exosomes

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Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
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Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

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Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
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Vesicular Tubular Clusters01:45

Vesicular Tubular Clusters

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After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
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Fusion of Secretory Vesicles with the Plasma Membrane01:26

Fusion of Secretory Vesicles with the Plasma Membrane

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Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
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Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

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Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
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Related Experiment Video

Updated: May 21, 2025

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
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In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

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Emerging interactions between circadian rhythms and extracellular vesicles.

Jacob G Smith1

  • 1Department of Cell Biology, Physiology and Immunology, School of Biology, University of Barcelona, Barcelona, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, Barcelona, Spain.

International Review of Cell and Molecular Biology
|May 20, 2025
PubMed
Summary
This summary is machine-generated.

Circadian rhythms influence extracellular vesicles (EVs), crucial for cell communication. This review explores how daily rhythms impact EV function and how EVs, in turn, signal back to circadian clocks.

Keywords:
Cell-cell communicationCircadian clocksCircadian rhythmsExosomesExtracellular vesiclesInter-organ crosstalk

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Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
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Last Updated: May 21, 2025

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Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
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Area of Science:

  • Chronobiology
  • Cellular Biology
  • Molecular Medicine

Background:

  • Circadian rhythms govern daily physiological processes and metabolic control.
  • Cell-to-cell communication is vital for tissue coordination, with extracellular vesicles (EVs) playing a key role.
  • The interplay between circadian rhythms and EV biology remains largely unexplored.

Purpose of the Study:

  • To review current knowledge on the influence of circadian rhythms on EV abundance, properties, cargo, and signaling.
  • To examine the feedback mechanisms of EV signaling on circadian clocks.
  • To identify knowledge gaps and suggest future research directions in this emerging field.

Main Methods:

  • Literature review of recent discoveries.
  • Analysis of studies investigating circadian regulation of EVs.
  • Exploration of research on EV-mediated signaling impacting circadian systems.

Main Results:

  • Emerging evidence suggests circadian rhythms affect EV abundance, cargo, and function.
  • EVs may play a role in transmitting circadian signals between cells and tissues.
  • Circadian clocks can be influenced by EV-mediated feedback signaling.

Conclusions:

  • The interaction between circadian rhythms and EVs is a significant, understudied area.
  • Further research is needed to elucidate the molecular mechanisms governing this relationship.
  • Understanding this interplay could reveal new therapeutic targets for metabolic and circadian disorders.