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Meeting report: DMDG peptide and oligonucleotide ADME workshop 2024

Inga Bjørnsdottir1, Ralf Lotz2, Bo Lindmark3

  • 1Development ADME, Novo Nordisk A/S, Måløv, Denmark.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
|May 20, 2025
PubMed

Keywords:
PKPD and PBPK modelling and hybrid LC-MS/MSPeptidesdrug-drug interactionsextrahepatic delivery of siRNAshuman unique metabolitein vitro assaysoligonucleotides

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PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure (CHF).