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Updated: Jun 12, 2025
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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Photo-induced aerobic cross-coupling of quinoxalin-2(1H)-ones with electron-rich thiophenes
Wei Huang1, Tong Wang1, Shu-Ying Chen1
1Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Taizhou, Zhejiang 318000, P. R. China. qzhou@tzc.edu.cn.
Abstract:
Herein, an economical and efficient protocol was developed for the aerobic oxidative cross-coupling of electron-rich thiophenes and quinoxazolines with the activation of two C-H bonds. No external photosensitizer was necessary for constructing the thiophenyl-quinoxazoline backbone. The substrate scope demonstrated the good functional tolerance of quinoxalin-2(1H)-ones, and suitable thiophenes for this coupling fall within the special spectrum of oxidative potentials lower than +1.50 V vs. SCE.
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