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Updated: Apr 17, 2026

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Electrochemical Synthesis of 7-Membered Cyclic Ethers via Selenocyclization of Propargylic Benzyl Ethers
Xia-Die Wu1, Meng-Yuan Wu1, Lei Wang1
1School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang 318000, P. R. China.
Abstract:
An electrochemical approach for the synthesis of seven-membered cyclic ethers through 7-endo-dig selenocyclization of propargylic benzyl ethers has been developed. The reactions are carried out at room temperature by employing diselenides as selenylation reagents, demonstrating good substrate suitability and functional group compatibility. Various 7-membered cyclic ethers are obtained with good regioselectivity and yields under metal-reagent-free and oxidant-free conditions. The utility of the reaction is further highlighted by gram-scale synthesis and diverse product transformations.
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