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Related Concept Videos

Flow Cytometry01:23

Flow Cytometry

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The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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Related Experiment Video

Updated: May 22, 2025

Author Spotlight: High-Quality Quantum Dot Nanobeads for Sensitive Fluorescent Lateral Flow Immunoassays
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Lateral Flow Device Aspergillus Routine Testing for Invasive Pulmonary Aspergillosis in Patients Who Are Critically

Stefan Hatzl1,2, Lisa Kriegl2,3, Christina Geiger3

  • 1Intensive Care Unit, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Open Forum Infectious Diseases
|May 20, 2025
PubMed
Summary

Rapid lateral flow assays show promise for diagnosing invasive pulmonary aspergillosis (IPA) in intensive care units (ICUs). While effective, this Aspergillus test requires complementary diagnostic methods for definitive IPA diagnosis.

Keywords:
ICUIPAbedside testinglateral flow devicerapid testing

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Area of Science:

  • Critical care medicine
  • Infectious diseases
  • Medical diagnostics

Background:

  • Invasive pulmonary aspergillosis (IPA) incidence is increasing in intensive care unit (ICU) patients.
  • Early diagnosis and treatment are crucial for improving survival rates.
  • Novel lateral flow assays for Aspergillus antigen detection offer rapid results, aiding clinical decision-making.

Purpose of the Study:

  • To evaluate the diagnostic performance of a bronchoalveolar lavage lateral flow device test for IPA in ICU patients.
  • To assess the utility of rapid antigen detection in a critical care setting.

Main Methods:

  • Retrospective multicenter study involving 180 ICU patients (48 with IPA, 132 controls).
  • Classification of fungal infections using the FUNDICU criteria.
  • Analysis of sensitivity, specificity, and predictive values of the lateral flow device test.

Main Results:

  • The lateral flow device test demonstrated a sensitivity of 71% and specificity of 98% for diagnosing probable IPA.
  • The area under the receiver operating characteristic curve was 0.84, indicating good diagnostic performance.
  • Positive and negative predictive values were 92% and 90%, respectively.

Conclusions:

  • Lateral flow device testing is a valuable tool for rapid IPA diagnosis in time-critical ICU settings.
  • The test is not sufficient to definitively rule out IPA.
  • A comprehensive diagnostic approach remains essential for managing IPA in ICU patients.