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Updated: Aug 17, 2026

Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging
09:05

Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging

Published on: June 21, 2016

Progression of hypertrophic cardiomyopathy. A cross sectional echocardiographic study

S Domenicucci, E Lazzeroni, J Roelandt

    British Heart Journal
    |April 1, 1985
    PubMed

    Insights

    Septal myotomy-myectomy effectively prevented hypertrophy progression in hypertrophic cardiomyopathy patients. Echocardiography accurately detected this progression, highlighting the surgical intervention

    Area of Science:

    • Cardiology
    • Medical Imaging

    Background:

    • Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy.
    • Understanding hypertrophy progression is crucial for patient management.
    • Echocardiography is a key diagnostic tool in cardiology.

    Purpose of the Study:

    • To investigate the progression of hypertrophy in patients with hypertrophic cardiomyopathy.
    • To evaluate the efficacy of medical treatment (propranolol) versus surgical intervention (septal myotomy-myectomy) in preventing hypertrophy progression.
    • To assess the role of echocardiography in detecting hypertrophy progression.

    Main Methods:

    • Echocardiography was used to study hypertrophy progression in 39 HCM patients over a mean follow-up of 42 months.
    • Patients were divided into two groups: 32 treated medically (propranolol) and 11 treated with septal myotomy-myectomy.
    • Electrocardiogram (ECG) changes were also monitored in patients with documented hypertrophy progression.

    Main Results:

    • Progression of hypertrophy was observed in four patients treated with propranolol.
    • These four patients showed significant ECG changes, including increased QRS voltages and Romhilt-Estes scores, or developed left bundle branch block.
    • None of the 11 patients who underwent septal myotomy-myectomy showed progression of hypertrophy.

    Conclusions:

    • Echocardiography is a reliable method for detecting hypertrophy progression in hypertrophic cardiomyopathy.
    • Septal myotomy-myectomy appears to prevent the progression of hypertrophy.
    • Medical management with propranolol did not prevent hypertrophy progression in this cohort.

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