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Published on: June 21, 2017
Copper-Catalyzed Dienylation of Aldehydes Using Propargylic Carbonates
Xiang Lei1, Peng Luo1, Wennan Dong2
1College of Chemistry, Fuzhou University, Fuzhou 350116, China.
None:
A copper-catalyzed dienylation of aldehydes using propargylic carbonates in the presence of B2pin2 has been successfully developed, enabling the synthesis of a diverse range of substituted 1,3-butadienyl-2-carbinols (BDCs). This innovative approach circumvents the requirement of allene reagents and provides an alternative protocol that allows access to BDCs. In addition, the synthetic value of the products has been demonstrated in a series of further conversions, and the reaction mechanism has been proposed based on control experiments.
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