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Ruthenium-Catalyzed Acyloin Isomerization via Borrowing Hydrogen
Jingjing Li1, Shouang Lan2, Jinggong Liu3
1College of Chemistry, Fuzhou University, Fuzhou350116, China.
Abstract:
Acyloin isomerization is an important transformation in carbohydrate chemistry, biological processes, and organic synthesis; however, the development of effective catalytic methods for this reaction remains challenging. In this work, we have successfully developed a ruthenium-catalyzed acyloin isomerization, which produces a range of α-hydroxyketones. These products can be further converted into a series of valuable molecules. In contrast to the conventional enediol mechanism, we propose that this reaction proceeds via a borrowing-hydrogen process, with a 1,2-diketone serving as the key intermediate.
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