Related Experiment Video
Updated: May 22, 2025
![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)
Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Nitrosoamine-3-Hydroxyflavothione Hybrids Enable Oxygen-Tolerant Photoredox Catalysis for Red-Light-Stimulated CO/NO
Ishaq Lugoloobi1, Jian Cheng1, Zhiqiang Shen1
1Department of Pharmacy, the First Affiliated Hospital of the USTC, Division of Life Sciences and Medicine; CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, Anhui 230026, China.
Abstract:
Single gas donors have proved to have vast therapeutic potential; however, the investigation of multigas releasing molecules is limited. Besides, porphyrins and their derivatives are essential energy and electron transfer agents for activating gaseous signaling molecule (GSM) donors, despite, the catalysis of the latter is greatly limited in oxygen-rich environments. We, therefore, report photosensitive small-molecule hybrids composed of oxo-/thio-flavonols as the singlet oxygen (1O2) scavengers for catalytic stability and N-nitrosoamine moieties for the competent co-release of carbon monoxide (CO) and nitric oxide (NO) in amounts that depend on the structural designs. The self-assembled micellar co-encapsulation of CO/NO donors and PdTPTBP afforded the intracellular GSMs delivery during red-light irradiation. The bactericidal effect of irradiated micelles against planktonic Gram-positive and Gram-negative bacteria displayed a significant killing rate of S. aureus via membrane hyperpolarization and rupture and achieved an excellent combination index of 0.44. This represents their high potential for biomedical applications.
More Related Videos
08:57A Novel Technique for Generating and Observing Chemiluminescence in a Biological Setting
Published on: March 9, 2017
08:32Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
Published on: March 16, 2017
Related Concept Videos
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
2° Amines to N-Nitrosamines: Reaction with NaNO2
Oxidation of Phenols to Quinones
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
Preparation of Amines: Reduction of Oximes and Nitro Compounds
Though catalytic hydrogenation can reduce nitrobenzenes, the reduction is nonselective in the presence of other functional groups. For instance, if nitrobenzene contains an aldehyde group,...