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Updated: May 22, 2025

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Transformation of a Potent C9-Substituted Phenylmorphan into MOR Partial Agonists with Improvement of Metabolic

Delmis E Hernandez1, Dan Luo2, Thomas E Prisinzano2

  • 1Department of Health and Human Services, Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9800 Medical Center Drive, Bethesda, Maryland 20892-3373, United States.

ACS Chemical Neuroscience
|May 20, 2025
PubMed

Keywords:
agonistsantagonistsbioisosteresmu opioid receptor (MOR)opioid use disorder (OUD)

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