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Updated: Jul 26, 2026

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
Published on: May 16, 2016
Endotoxin hemoadsorption in refractory septic shock with multiorgan dysfunction and extreme endotoxin activity
Juan Carlos Ruiz-Rodríguez1,2,3, Luis Chiscano-Camón4,5,6, Ivan Bajaña1,2
1Intensive Care Department, Vall d'Hebron Hospital Campus, Vall d'Hebron University Hospital, Barcelona, Spain.
Abstract:
Endotoxin septic shock is marked by severe organ failure and mortality rate that exceeds fifty percent, underscoring the critical need to tailor management strategies. Monitoring -endotoxin activity can guide the initiation and direction of adjunctive treatment for refractory septic shock through hemoadsorption. Thus, intervening based on the pathophysiological foundation may potentially improve outcomes. This represents a step towards precision medicine in the management of septic shock adjunctive therapies, addressing a knowledge gap in this pathology that remains insufficiently defined. Despite its potential, in the setting of refractory septic shock and multiorgan dysfunction with extreme endotoxin activity (EAA ≥ 0.9), the data about efficacy of endotoxin hemoadsorption is scarce.
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