Protein-Based Multifunctional Hydrogel Adhesive for Wound Healing.

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Tissue Engineering

Background:

• Wound healing involves complex stages: hemostasis, inflammation, proliferation, and remodeling.
• Effective wound management requires advanced bioadhesive materials.
• Hydrogel bioadhesives offer promising properties for wound treatment, but protein-based options are under-explored.

Purpose of the Study:

• To systematically review the design principles and functions of ideal hydrogel bioadhesives for wound repair.
• To provide an overview of recent advancements in multifunctional protein-based hydrogel bioadhesives.
• To evaluate the practical performance and future directions of these biomaterials.

Main Methods:

• Literature review of protein-based hydrogel bioadhesives for wound healing.
• Analysis of design principles and essential functions in wound repair.
• Evaluation of hydrogel performance derived from collagen, silk fibroin, sericin, fibrin, gelatin, keratin, and casein.

Main Results:

• Protein-based hydrogels exhibit excellent physical properties and biocompatibility for wound healing applications.
• Various proteins like collagen, silk fibroin, and gelatin are utilized to create advanced hydrogel bioadhesives.
• These hydrogels demonstrate significant potential in promoting tissue repair and restoring integrity.

Conclusions:

• Protein-based hydrogel bioadhesives represent a significant advancement in wound healing technology.
• Further research is needed to overcome challenges and facilitate clinical translation.
• Continued development aims to enhance the efficacy and application of these biomaterials in comprehensive wound management.