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Understanding the Mechanism of Cardiotoxicity Induced by Nanomaterials: A Comprehensive Review
Zaiyong Zheng1,2, Shuang Zhu3,4, Xiaobo Wang2
1Department of Cardiology Key Laboratory of Medical Electrophysiology Ministry of Education, Basic Medicine Research Innovation Center for Cardiometabolic Diseases Ministry of Education, The Affiliated Hospital of Southwest Medical University Southwest Medical University Luzhou 646000 China.
Small Science
|May 21, 2025
Summary
Nanomaterials can harm the heart, a critical area of concern. This review details cardiovascular nanotoxicity mechanisms and mitigation strategies for safer nanotechnology applications.
Area of Science:
- Nanotechnology
- Cardiovascular Science
- Toxicology
Background:
- Nanomaterials are increasingly prevalent in daily life, posing potential health risks.
- The circulatory system, particularly the heart, is vulnerable to nanotoxicity due to unique nanomaterial properties.
- Understanding cardiovascular nanotoxicity is crucial for the safe advancement of nanotechnology.
Purpose of the Study:
- To provide a comprehensive review of nanomaterial-induced cardiotoxicity.
- To identify current research trends and hotspots in cardiovascular nanotoxicity.
- To elucidate the mechanisms and propose mitigation strategies for nanotoxicity.
Main Methods:
- Bibliometric analysis to identify research trends and hotspots.
- Literature review focusing on cardiovascular nanotoxicity mechanisms.
- Discussion of exposure routes, cellular damage, and inflammatory responses.
- Review of strategies for mitigating nanotoxicity.
Main Results:
- Bibliometric analysis revealed key research areas in cardiovascular nanotoxicity.
- Mechanisms discussed include membrane injury, ion imbalance, oxidative stress, inflammation, and cell death.
- Various exposure routes contribute to cardiac adverse effects.
- Current mitigation strategies aim to reduce nanomaterial-induced harm.
Conclusions:
- Cardiovascular nanotoxicity is a significant concern requiring further investigation.
- Understanding the mechanisms is essential for developing effective safety measures.
- This review provides a foundation for future research and the safe application of nanomaterials in healthcare and industry.
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