The price of WAR: AMR
Laura J Rojas1,2,3, Tracy L Lemonovich4,5, Steven H Marshall3
1Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Background:
The ongoing conflict in Ukraine has exacerbated the risk of MDR bacterial infections in war-injured patients.
Methods:
We present the case of a Ukrainian soldier who sustained a traumatic explosive injury to the bilateral lower extremities, underwent surgery and subsequently experienced an infection with a carbapenem-resistant Klebsiella pneumoniae. The isolate was subject to genomic WGS.
Results:
This case study describes the successful management of a traumatic injury in a Ukrainian soldier infected with a carbapenem-resistant K. pneumoniae isolated from surgical wounds. WGS revealed a hypervirulent ST147 strain carrying multiple resistance and virulence factors, including bla NDM-1. Treatment with ceftazidime/avibactam and aztreonam was effective.
Conclusions:
Ceftazidime/avibactam and aztreonam is highlighted as a promising regimen for MDR infections in conflict zones.
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