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Updated: Aug 13, 2026

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
Published on: October 7, 2011
Tupaia GBP1 exploits autophagy to restrict herpes simplex virus type 1 infection
Tianle Gu1,2, Yong-Gang Yao1,2,3
1Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, and KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Kunming, Yunnan 650204, China.
Abstract:
Macroautophagy/autophagy initiated by STING1 (stimulator of interferon response cGAMP interactor 1) is actively involved in viral infection; and it is known that interferon-inducible guanylate-binding proteins (GBPs) exploit autophagy to defend the host against bacterial infection. Here we showed that in the tree shrew (Tupaia belangeri), a close relative to primates, TbGBP1 (T. belangeri GBP1) interacts with TbSTING1 to initiate autophagy and inhibit herpes simplex virus type 1 (HSV-1) infection.
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