Interplay between lipid profiles, thyroid function, and gallstone disease: A clinical perspective.

Area of Science:

• Endocrinology
• Gastroenterology
• Metabolic Disorders

Background:

• Gallstone disease (GSD) presents a complex interplay with thyroid function and lipid profiles.
• Understanding these relationships is key for effective GSD prevention and treatment strategies.

Purpose of the Study:

• To investigate the prevalence of thyroid abnormalities in GSD patients.
• To examine the association between thyroid dysfunction and dyslipidemia in this cohort.

Main Methods:

• A cross-sectional observational study involving 60 GSD patients at a tertiary care hospital.
• Patients were categorized by gallstone type and thyroid status (euthyroid, subclinical/clinical hypothyroidism).
• Dyslipidemia was defined by elevated triglycerides (>150 mg/dL) or total cholesterol (>200 mg/dL).

Main Results:

• Subclinical hypothyroidism was present in 13.33% of patients; no clinical hypothyroidism was observed.
• 100% of patients with subclinical hypothyroidism exhibited dyslipidemia, compared to 36.5% of euthyroid patients.
• Elevated total cholesterol significantly correlated with subclinical hypothyroidism (P < 0.05) and obesity (P = 0.04).

Conclusions:

• Thyroid function status is vital for managing lipid abnormalities in gallstone patients, despite no direct association with gallstone type.
• Thyroid function influences both gallstone formation and lipid metabolism.
• These findings offer valuable clinical insights for GSD management.