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Related Concept Videos

Pulse01:16

Pulse

407
When the heart pumps blood out, arterial elastic fibers play a crucial role in sustaining a high-pressure gradient. They expand to accommodate the received blood and then recoil - a process known as the pulse that can be either manually palpated or electronically quantified. Despite a reduction in its effect with increased distance from the heart, elements of the pulse's systolic and diastolic components persist, observable even at the arteriole level.
The pulse serves as a clinical...
407
Pulse amplitude and quality01:17

Pulse amplitude and quality

1.5K
Pulse amplitude is a crucial indicator of cardiac health because it provides valuable insights into the strength of left ventricular contractions and the overall uniformity of blood circulation within the vasculature. The strength of the pulse is directly related to the force with which the heart contracts and the volume of blood being pumped.
A weak or absent pulse may indicate reduced cardiac output or poor left ventricular contraction, which can be signs of cardiovascular dysfunction or...
1.5K
Special considerations while measuring pulse01:13

Special considerations while measuring pulse

551
Assessing a patient's pulse is a fundamental skill in healthcare, but certain situations require special attention:
551
Pulse rhythm01:30

Pulse rhythm

743
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
743
Correlation between ECG and Cardiac Cycle01:25

Correlation between ECG and Cardiac Cycle

3.0K
The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
3.0K
Equipments Used To Measure Blood Pressure01:30

Equipments Used To Measure Blood Pressure

778
Direct Method
This invasive approach involves cannulating a peripheral artery. During each cardiac contraction, pressure generates mechanical motion within the catheter, transmitted through rigid, fluid-filled tubing to a transducer. This transducer converts mechanical motion into electrical signals displayed as waveforms on a monitor. An automatic flushing system prevents blood backflow. Due to the potential risk of unexpected arterial blood loss, this method is primarily used in intensive...
778

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Updated: May 22, 2025

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
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Predicting Coronary Artery Lesion Severity using Pulse Wave Harmonics: A SYNTAX Score-based Study.

Haitian Li1,2, Buxing Chen2, GinChung Wang3

  • 1Beijing University of Chinese Medicine, Beijing, 100029, China.

Current Cardiology Reviews
|May 21, 2025
PubMed
Summary
This summary is machine-generated.

Differences in pulse wave harmonics between hands can predict coronary artery disease severity. This noninvasive method offers a valuable tool for assessing coronary artery lesions and aiding clinical diagnosis.

Keywords:
Arterial pressure waveROC curve.SYNTAX scoredegree of coronary artery lesionsharmonicsphotoplethysmography

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Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
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Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

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Area of Science:

  • Cardiovascular Medicine
  • Biomedical Engineering
  • Medical Diagnostics

Background:

  • Coronary artery disease (CAD) assessment often relies on invasive procedures.
  • Noninvasive methods for evaluating coronary artery lesion severity are highly sought after.
  • Pulse wave analysis offers a potential noninvasive approach to cardiovascular assessment.

Purpose of the Study:

  • To investigate the correlation between pulse wave harmonic index differences (left vs. right hand) and the SYNTAX score.
  • To explore the predictive potential of pulse wave harmonics for coronary artery lesion severity.
  • To develop a noninvasive diagnostic model for CAD assessment.

Main Methods:

  • Photoplethysmography recorded arterial pressure wave signals from both hands.
  • Fourier transform decomposed waves into 0th-11th harmonics (amplitude, phase, energy).
  • Differences in harmonic indices between hands were calculated and analyzed using logistic regression and ROC curves, stratified by gender.

Main Results:

  • Developed gender-specific predictive models for coronary artery lesion severity (SYNTAX score ≥22).
  • Male group model: AUC 0.89 (Bootstrap 0.85), based on specific harmonic index differences.
  • Female group model: AUC 0.92 (Bootstrap 0.84), based on different harmonic index differences.

Conclusions:

  • Differences in pulse wave harmonics between hands effectively reflect coronary artery lesion severity.
  • A diagnostic model using pulse wave harmonic analysis demonstrates good discriminant ability for CAD.
  • This noninvasive method provides a valuable tool for clinical assessment of coronary artery disease.