Related Experiment Video

Updated: May 23, 2025

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
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Impact of Modifying Lazertinib Doses on Effectiveness and Safety in Patients With EGFR-Positive Advanced Lung Cancer:

Mi-Hyun Kim1, Min Ki Lee1, Ji Eun Park2

  • 1Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea.

Thoracic Cancer
|May 21, 2025
PubMed
Abstract

Insights

This study investigates lazertinib dose adjustments in non-small-cell lung cancer (NSCLC) patients. It examines how modifying the dose impacts treatment effectiveness and safety in real-world clinical settings.

Area of Science:

  • Oncology
  • Pharmacology
  • Clinical Medicine

Background:

  • Lazertinib is a third-generation EGFR tyrosine kinase inhibitor used for EGFR-mutant NSCLC.
  • The impact of lazertinib dose modification on efficacy and safety requires further investigation.

Purpose of the Study:

  • To evaluate the clinical implications of lazertinib dose adjustments.
  • To understand factors influencing dose modification in routine practice.
  • To assess the efficacy and safety of different lazertinib doses.

Main Methods:

  • Prospective, multicenter, observational cohort study.
  • Patients divided into 160 mg and 240 mg lazertinib dose groups.
  • Primary endpoints: progression-free survival and risk factors for dose modification within 12 weeks.

Main Results:

  • This section is to be filled upon study completion.

Conclusions:

  • Study findings will offer real-world insights into lazertinib dose adjustments.
  • Enhanced understanding of lazertinib efficacy and safety in NSCLC patients.
  • Aids in optimizing NSCLC treatment strategies and clinical decision-making for dose modifications.
Keywords:
dose modificationepidermal growth factor receptorlazertinibtreatment outcome

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