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Updated: Jun 17, 2026
Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
Published on: March 20, 2015
Recent advances of metal cluster-based SERS probes for biomedical applications
Li Sun1, Songchen Zhao2, Shishuai Zheng1
1Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Zhejiang International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Sciences (CAS), Key Laboratory of Magnetic Materials and Devices, Ningbo Cixi Institute of Biomedical Engineering, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, PR China. linjie@nimte.ac.cn.
Abstract:
Surface-enhanced Raman scattering (SERS), as a revolutionary technology, has made remarkable progress in the field of biomedical applications in recent years, particularly in the development and functional applications of metal cluster-based substrates. This review systematically summarizes the latest advancements in the SERS field, focusing on advanced substrate materials and their enhancement mechanisms. Special attention is given to the biomedical applications of metal cluster-based substrates in SERS sensing and imaging. The role of density functional theory (DFT) in uncovering the enhancement mechanisms is also discussed. Finally, the current challenges of metal cluster-based SERS probes are analyzed and the future prospects of their applications in high-sensitivity detection, precision medicine, and multimodal imaging are explored. This review provides valuable theoretical and experimental insights for the further development and application of metal cluster-based SERS technology.
