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Factors associated with mortality in patients with cardiovascular diseases affected by COVID-19: a cross-sectional

Mariane Cardoso Carvalho1,2, Flávia Emília Cavalcante Valença Fernandes1, Matheus Vargas Dos Santos Almeida1

  • 1Universidade de Pernambuco, Campus Petrolina, Petrolina, PE, Brazil.

Revista Latino-Americana De Enfermagem
|May 21, 2025
PubMed

Insights

Cardiovascular disease patients with Coronavirus Disease-2019 face higher mortality risks. Male gender, older age, white ethnicity, and multiple comorbidities significantly increase the chance of death in this vulnerable population.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Cardiovascular disease (CVD) patients are a vulnerable group during infectious disease outbreaks.
  • Coronavirus Disease-2019 (COVID-19) has shown a significant impact on individuals with pre-existing health conditions.

Purpose of the Study:

  • To identify factors associated with mortality in patients with cardiovascular disease who contracted COVID-19.
  • To analyze the specific demographic and clinical characteristics that predict adverse outcomes in this patient cohort.

Main Methods:

  • Cross-sectional study utilizing pandemic notification data.
  • Inclusion of cases with cardiovascular comorbidity and documented clinical outcomes.
  • Binary logistic regression analysis with Odds Ratio to determine associations with mortality.

Main Results:

  • Prevalence data showed a majority of female (50.6%), elderly (71.1%), and non-white (71.0%) patients.
  • Multiple comorbidities, particularly diabetes (44.8%), were common (60.3%).
  • Increased mortality risk was associated with male gender (OR 1.13), older age (OR 2.57), white ethnicity (OR 1.71), and multiple comorbidities (OR 1.70).

Conclusions:

  • Mortality in cardiovascular disease patients with COVID-19 is significantly influenced by gender, age, and the presence of comorbidities.
  • These findings highlight the heightened vulnerability of this population to severe outcomes from COVID-19 infection.

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