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Updated: May 22, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Hepatoprotective diterpenes from the nodes of Pinus massoniana
Jia-Qi Chen1, Ling-Zhi Zhang1, Jie Ma1
1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Abstract:
Three new diterpenes, named pinusins D-F (1-3), were isolated from the Chinese medicine "Pini Lignum Nodi" (the dried tuberculate or branched nodes of Pinus massoniana), along with twelve known diterpenes. The structures of these new compounds were determined using detailed spectroscopic methods and ECD calculations. Compounds 4-15 displayed moderate hepatoprotective activity against H2O2-induced oxidative damage in HepG2 cells, while compounds 5-15 exhibited markedly enhanced efficacy -surpassing that of bicyclol (positive control).
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