Perovskite-Graphene Heterostructure Biosensor Integrated with Biotunable Nanoplasmonic Ternary Logic Gate for...

Area of Science:

• Materials Science
• Nanotechnology
• Biomedical Engineering

Background:

• 2D materials and optoelectronic devices are crucial for advanced applications.
• Perovskite/graphene heterostructures offer unique properties for device integration.

Purpose of the Study:

• To develop the first perovskite/graphene heterostructure-based FET biosensor.
• To achieve biotunable ternary logic gating functionality for enhanced detection.

Main Methods:

• Integration of a perovskite quantum dots (PQDs)/single-layer graphene (SLG) phototransistor with a bio-nano-photonic filter.
• Utilizing localized surface plasmon resonance (LSPR) induced by gold nanoparticles (AuNPs) and antigen-antibody binding.
• Detection of human interleukin-6 (IL6) for sensitivity assessment.

Main Results:

• Achieved ultrahigh sensitivity with a limit of detection (LOD) of 0.9 fg mL⁻¹ (43 aM) for IL6 detection.
• Demonstrated synergistic effects of the PQDs/SLG heterostructure for superior performance.
• Exhibited label-free detection with rapid responsivity (5 min), excellent stability, and selectivity.

Conclusions:

• The developed biosensor offers a new platform for next-generation bio-nano-photonic applications.
• This technology holds promise for healthcare, early diagnosis, and rapid detection systems.
• The biotunable heterostructure configuration advances the use of 2D materials in biosensing.