Related Experiment Video
Updated: May 3, 2026

Protocol for the Direct Conversion of Murine Embryonic Fibroblasts into Trophoblast Stem Cells
Published on: July 25, 2016
3D In Vitro Culture of Early Mouse Embryos and Trophoblast Tissue Explants
Devila Prit1, Shashank Jaitly1, Niraimathi Govindasamy1
1Embryonic Self-Organization Research Group, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
None:
The cellular dynamics during peri-implantation embryogenesis and the concurrent interactions at the embryo-maternal interface are inherently difficult to study due to intrauterine development in mammals. To model certain aspects of these processes in vitro, we have generated a biomimetic environment resembling the mechanical properties of the murine uterine stroma. Here we describe a step-by-step methodology for 3D culture of mouse embryos and ectoplacental cone explants in synthetic hydrogels that allow ex utero trophoblast invasion.
Related Concept Videos
Coagulation
Coagulation
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...

