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ÆMMamba: An Efficient Medical Segmentation Model With Edge Enhancement
IEEE Journal of Biomedical and Health Informatics
|May 21, 2025
Summary
ÆMMamba, a new framework for medical image segmentation, improves accuracy by effectively modeling long-range dependencies. It achieves state-of-the-art results on multiple datasets for polyp, lung, breast, and brain tumor segmentation.
Area of Science:
- Medical Image Analysis
- Artificial Intelligence
- Computer Vision
Background:
- Accurate medical image segmentation is vital for clinical applications but challenged by image complexity.
- Existing methods like CNNs and Vision Transformers have limitations in modeling long-range dependencies efficiently.
- State Space Models offer potential for efficient long-range dependency modeling.
Purpose of the Study:
- To introduce ÆMMamba, a novel multi-scale feature extraction framework for enhanced medical image segmentation.
- To address the limitations of current models in capturing both local and global image features.
- To improve segmentation accuracy across diverse medical imaging modalities and datasets.
Main Methods:
- Developed ÆMMamba based on the Mamba backbone, incorporating an Efficient Fusion Bridge (EFB) for multi-scale feature fusion.
- Integrated an Edge-Aware Module (EAM) using Sobel-based edge extraction to enhance low-level features.
- Utilized a Boundary Sensitive Decoder (BSD) with inverse attention and residual convolutions for complex boundary handling.
Main Results:
- ÆMMamba achieved state-of-the-art performance on 8 medical segmentation datasets.
- Demonstrated superior performance in polyp segmentation (e.g., 72.22 mDice on ETIS) compared to MADGNet and Swin-UMamba.
- Outperformed H2Former and SwinUnet in lung and breast segmentation (e.g., 84.24 Dice on BUSI, 79.83 on COVID-19 Lung).
- Achieved high scores on LGG brain MRI segmentation (87.25 mDice, 79.31 mIoU).
Conclusions:
- ÆMMamba represents a significant advancement in medical image segmentation, outperforming existing methods.
- The proposed framework effectively integrates multi-scale features and boundary information for robust segmentation.
- ÆMMamba shows great potential for various clinical applications requiring precise image segmentation.

