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Updated: Jul 10, 2026
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Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
Published on: May 11, 2018
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Ventricular Assist Device Use in Pediatric Restrictive and Hypertrophic Cardiomyopathy: An ACTION Registry Analysis
Deepa Mokshagundam1, Muhammad F Shezad2, Jennifer Conway3
1From the St Louis Children's Hospital, St Louis, Missouri.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|May 21, 2025
Summary
Ventricular assist devices (VADs) offer a viable option for pediatric restrictive cardiomyopathy (RCM) patients, but outcomes for hypertrophic cardiomyopathy (HCM) are less favorable. This study analyzes VAD use in these rare pediatric heart conditions.
Area of Science:
- Pediatric Cardiology
- Mechanical Circulatory Support
- Cardiomyopathy Research
Background:
- Ventricular assist devices (VADs) are rarely used in pediatric restrictive (RCM) and hypertrophic cardiomyopathy (HCM).
- Understanding VAD outcomes in these specific pediatric populations is crucial for treatment strategies.
Purpose of the Study:
- To describe the outcomes of pediatric patients with RCM and HCM who received VAD support.
- To evaluate the safety and efficacy of VADs in this rare cohort.
Main Methods:
- Retrospective analysis of 34 pediatric patients with RCM or HCM receiving VADs.
- Data collected from the Advanced Cardiac Therapies Improving Outcomes Network (ACTION) registry (March 2012-December 2024).
- Included left-sided VAD (LVAD), biventricular VAD (BiVAD), and total artificial heart (TAH) devices.
Main Results:
- 25 patients had RCM, 9 had HCM; median age 2.5 years, weight 11.8 kg.
- High illness severity at implant: 38.2% INTERMACS profile 1, 41.2% on ECMO.
- Transplant rate was 73.5%; 11.8% died on device, 11.8% alive on device.
Conclusions:
- VAD support is a reasonable strategy for select pediatric RCM patients.
- Outcomes for pediatric HCM patients on VADs were less favorable, with deaths linked to HCM diagnosis, BiVAD support, and adverse events.
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