Fibrin Glue-Assisted Pretreated Lyophilized Human Amniotic Membrane Technique for Retinal Detachment With Inferior...

Area of Science:

• Ophthalmology
• Regenerative Medicine
• Surgical Innovation

Background:

• Inferior retinal breaks (IRBs) present unique challenges in retinal detachment (RD) surgery.
• Traditional methods for RD repair may involve intraocular tamponade (e.g., silicone oil) and require specific post-operative positioning.
• Novel biomaterials and surgical adjuncts are needed to improve RD treatment outcomes.

Purpose of the Study:

• To evaluate the efficacy and safety of using fibrin glue-assisted pre-treated lyophilized human amniotic membrane (LhAM) for retinal detachment caused by inferior retinal breaks.
• To assess the potential of LhAM as a substitute for traditional intraocular tamponades.

Main Methods:

• Retinal breaks were sealed with intraocular photocoagulation post-reattachment.
• Lyophilized human amniotic membrane (LhAM) grafts were pre-treated with hypertonic glucose and fibrin glue A.
• Grafts were applied to cover or implant under breaks, secured with fibrin glue B, potentially using perfluorocarbon liquid (PFCL).

Main Results:

• All cases achieved successful retinal reattachment.
• Median best-corrected visual acuity improved significantly from 20/200-20/130 to 20/30.
• Minor complications included one graft displacement and fibrin glue residue in two cases; one patient had mild uveitis.

Conclusions:

• Fibrin glue-assisted pre-treated LhAM is effective for achieving anatomical reattachment in RDs from IRBs.
• This technique eliminates the need for intraocular silicone oil tamponade.
• The method does not require strict post-operative positioning, simplifying patient management.