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CSDE1 enhances genotoxic drug resistance in cancer by modulating RPA2 through CSDE1-eIF3a regulatory complex

Jia-Jia Cui1, Cheng-Xian Guo2, Jun Li3

  • 1Department of Geratic Surgery, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, Hunan 410008, PR China; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan 410008, PR China; Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha, Hunan 410000, PR China; Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China; Shenzhen Key Laboratory of Chinese Medicine Active substance screening and Translational Research, Shenzhen 518000, PR China.

Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
|May 21, 2025
PubMed
Abstract

Keywords:
CSDE1DNA repairGenotoxic drugsRPA2cGAS-STING

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