Causal association between depression and myalgia-related disorders: A bidirectional mendelian randomization study

Area of Science:

• Genetics and Epidemiology
• Mental Health Research
• Musculoskeletal Disorders

Background:

• The causal links between depression and myalgia-related disorders are not well understood.
• Investigating these relationships is crucial for developing effective treatment strategies.

Purpose of the Study:

• To examine the bidirectional causal relationship between depression and five myalgia-related disorders.
• To utilize Mendelian randomization (MR) for robust genetic analysis.

Main Methods:

• Two-sample Mendelian randomization (MR) analysis using genome-wide association study (GWAS) data for depression.
• Employed inverse variance-weighted (IVW), MR Egger, weighted median, and weighted mode methods for analysis.
• Conducted heterogeneity, pleiotropy, and sensitivity analyses to ensure reliability.

Main Results:

• Depression was causally linked to increased risks of myalgia, fibromyalgia, and osteoarthritis.
• Osteoarthritis showed a potential causal association with increased depression risk.
• No significant causal links were found between depression and myositis or rheumatoid arthritis.

Conclusions:

• A genetic causal relationship exists between depression and higher risks of myalgia, fibromyalgia, and osteoarthritis.
• Osteoarthritis may contribute to depression, indicating a potential bidirectional association.
• Effective depression management is vital for reducing the incidence of myalgia-related conditions.