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Updated: May 23, 2025

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
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Multiple Functions of Cell Adhesion Molecule 1 (CADM1) and Its Role in the Pathogenesis of Cancer and Other Diseases

Yoshinori Murakami1, Yutaka Kasai1, Tomoko Masuda1

  • 1Department of Molecular Biology, Institute for Advanced Medical Sciences, Nippon Medical School.

Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi
|May 21, 2025
PubMed

Insights

Cell adhesion molecule 1 (CADM1) functions as a tumor suppressor in many cancers but is overexpressed in adult T-cell leukemia/lymphoma and small cell lung cancer, highlighting its dual role in disease.

Area of Science:

  • Molecular Biology
  • Immunology
  • Oncology

Background:

  • Cell adhesion molecule 1 (CADM1) is an immunoglobulin superfamily member involved in cell adhesion and epithelium formation.
  • CADM1 acts as a tumor suppressor in epithelial cancers but is aberrantly expressed in certain hematologic and neuroendocrine tumors.

Purpose of the Study:

  • To summarize the diverse functions of CADM1.
  • To review CADM1's involvement in cancer and other diseases, particularly those related to aberrant cell adhesion.

Main Methods:

  • Literature review and synthesis of existing research on CADM1.
  • Analysis of CADM1 expression patterns in various cancers and non-cancerous tissues.
  • Examination of CADM1's molecular interactions and signaling pathways.

Main Results:

  • CADM1 exhibits tumor-suppressive roles through cell adhesion and as a tumor antigen recognized by immune cells.
  • CADM1 is downregulated in many epithelial cancers but upregulated in adult T-cell leukemia/lymphoma (ATL) and small cell lung cancer (SCLC).
  • Aberrant CADM1 expression is linked to male infertility and autism spectrum disorder.

Conclusions:

  • CADM1 plays multifaceted roles in cell adhesion, cancer development, and neurological functions.
  • CADM1's differential expression in various diseases suggests its potential as a diagnostic marker and therapeutic target.
  • Understanding CADM1's complex functions is crucial for addressing disorders of aberrant cell adhesion.
Keywords:
CADM1immunoglobulin superfamily cell adhesion molecule (IgCAM)small cell lung cancertumor immunitytumor suppressor gene

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