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Updated: May 23, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
Published on: October 6, 2023
Extraordinarily High Brain Natriuretic Peptide (BNP) Level in a Case of Thyroid Storm
Hiroaki Ishii1, Katsuhiko Ohashi2
1Department of Diabetes, Endocrinology and Metabolism, Azumino Red Cross Hospital, Azumino, JPN.
Abstract:
Thyroid storm is an extreme manifestation of thyrotoxicosis and represents a life-threatening endocrine emergency. Here, we report a 51-year-old woman with severe thyrotoxicosis and markedly elevated brain natriuretic peptide (BNP) level of 9950 pg/mL. Cardiac evaluation revealed poor left ventricular systolic performance. While thyroid function can affect BNP level, such extreme elevation is rare in cases of thyrotoxic crisis. This case highlighted the discrepancy between the clinical course and BNP level, emphasizing the need to recognize that BNP level may not always accurately reflect cardiac function in thyroid storm.
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