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Updated: May 23, 2025

A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts
Published on: February 17, 2023
Case Report: Refractory Ventricular Fibrillation Resolved by Double External Defibrillation and Beta Blockade
Humza Khan1, Jennifer Campoli1, Susan Wojcik1
1Upstate Medical University, Department of Emergency Medicine, Syracuse, New York.
Double external defibrillation (DED) combined with esmolol beta blockade offers a potential new treatment for refractory ventricular fibrillation (RVF). This case report shows promising results for this novel approach in a critical cardiac emergency.
Area of Science:
- Cardiology
- Emergency Medicine
- Pharmacology
Background:
- Refractory ventricular fibrillation (RVF) has a high mortality rate, often exceeding 97%.
- Current treatment for RVF lacks a universally accepted protocol beyond standard defibrillation and medications like amiodarone and epinephrine.
- A novel approach involving double external defibrillation (DED) and esmolol-induced beta blockade has emerged in limited case reports since 2015.
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