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Plasma prolactin levels during conditioned avoidance behavior in rats.

D B Yelvington, G K Weiss, A Ratner

    Physiology & Behavior
    |March 1, 1985
    PubMed
    Summary
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    Stress impacts prolactin (PRL) levels during learning. In rats, PRL increased initially with a conditioned avoidance response (CAR) task but normalized as they learned to avoid stress.

    Area of Science:

    • Neuroscience
    • Endocrinology
    • Behavioral Science

    Background:

    • The stress response involves hormonal changes, including prolactin (PRL).
    • Conditioned avoidance responses (CARs) are learned behaviors to prevent aversive stimuli.
    • Understanding the interplay between stress, learning, and hormonal responses is crucial.

    Purpose of the Study:

    • To investigate prolactin (PRL) level changes during the acquisition of a conditioned avoidance response (CAR) in rats.
    • To determine if behavioral adaptation to stress influences the PRL response.

    Main Methods:

    • Rats were trained in a two-way shuttle box to perform a CAR, involving a light cue followed by footshock.
    • Blood samples were collected via indwelling cannula for radioimmunoassay analysis of PRL levels.

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  • Behavioral performance (CARs) and PRL levels were monitored throughout the acquisition period.

    • Main Results:

    • PRL levels significantly increased during the initial stages of CAR acquisition, correlating with the rats' inability to avoid the footshock.
    • Following one week of training, CAR performance improved substantially (70% CARs).
    • Despite improved behavioral avoidance, PRL levels remained stable, indicating a dissociation between stressor exposure and hormonal response.

    Conclusions:

    • The study demonstrates that the prolactin (PRL) response is modulated by the learning process in a stressful situation.
    • As rats acquired the conditioned avoidance response (CAR), their physiological stress response, indicated by PRL levels, adapted.
    • These findings highlight the brain's capacity to regulate hormonal responses to stressors based on learned coping mechanisms.