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High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Cross-reactivity of urine opiates screening assays with dextromethorphan
Kelsey Marshall1, Katharine Van Patten2, Jesse C Seegmiller3
1HealthPartners, Bloomington, MN, USA.
Abstract:
We present a case of high-dose dextromethorphan ingestion with associated rapid urine drug screening and confirmatory testing demonstrating an apparent false-positive opiates screen. Further testing was performed using alternative screening assays and analysis of drug-free matrices spiked with various concentrations of dextromethorphan and its metabolite, dextrorphan. Results demonstrate a subset of urine opiates screening assays may be susceptible to dextromethorphan cross-reactivity at high concentrations.
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