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Updated: Jan 18, 2026

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
Published on: April 21, 2023
The Dance of Promoters and Enhancers in Gene Regulation: Fast or Slow, Entwined or Distant?
1Department of Functional Genomics and Cancer, Institute of Genetics and Molecular and Cellular Biology (IGBMC), UMR7104, Centre National de la Recherche Scientifique, U1258, Institut National de la Santé et de la Recherche Médicale, University of Strasbourg, 6704 Illkirch, France.
Abstract:
Gene regulation involves a dynamic and precise choreography, with enhancers and promoters moving through the nuclear landscape in search of functional encounters. Advances in live-cell imaging have revealed that they do not follow universal rules, but instead explore their environment with peculiar specificity. Yet we are still far from understanding how this motion translates into transcriptional output. How do enhancers find and activate their target genes? Are these processes coordinated or independent? This review studies the evolving view of enhancer-promoter dynamics, focusing on the insights from cutting-edge imaging techniques and the challenges of capturing their fleeting movements in real time.
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