Age-dependent changes in the level of a 34 kDa DNA-binding protein in developing chick embryo liver

The relative amounts of a DNA-binding protein of 34 kDa increased during the early stages of development of chick embryo liver. The content of this protein reached a maximum in 18-19-day-old embryonic livers and decreased afterwards in older embryonic and post-natal chick livers. The 34 kDa polypeptide is the major DNA-binding protein (DBP) of embryonic liver and it preferentially binds to single-stranded DNA. The quantity of the 34 kDa DBP was relatively very low in embryonic muscle, heart and brain.