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Updated: Sep 20, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Rhodium catalyzed sequential dual C-H annulation of 3-arylisoxazoles with 1,6-diynes to access fused naphthalenes
Ramesh Kotipalli1,2, T Mahipal Reddy1,2, Jagadeesh Babu Nanubolu3
1Department of OSPC, CSIR-Indian Institute of Chemical Technology, Habsiguda, Hyderabad 500007, India. msreddy@iict.res.in.
Abstract:
Selective dual C-H annulations with 1,n-diunsaturated systems represent a powerful tool for constructing multicyclic scaffolds in an expeditious manner. Here, we report a rhodium catalyzed sequential dual C-H annulation of 3-arylisoxazoles with 1,6-diynes for napthofused polycyclic systems. Some kinetic isotopic experiments were carried out to understand the reaction mechanism and some downstream experiments were conducted to demonstrate the potential of the methodology. The method features a broad substrate scope and scale-up capability.
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