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Updated: Apr 22, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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Published on: January 19, 2016

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Higher-Order [10 + 2] Annulation Strategy for the Synthesis of CF3-Functionalized Benzopentalenes

Jaggaraju Prudhviraj1,2, Chavakula Nagababu1,2, Jagadeesh Babu Nanubolu2,3

  • 1Fluoro-Agro Chemicals Division, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500007, India.

Organic Letters
|April 21, 2026
PubMed
Summary

This study introduces a new reaction for creating trifluoromethylated benzopentalenes using indene-2-carbaldehydes and palladium complexes. This method provides efficient access to complex fluorinated polycycles with high selectivity.

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