Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lysosomal Hydrolases01:22

Lysosomal Hydrolases

3.9K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.9K
Smooth Endoplasmic Reticulum01:21

Smooth Endoplasmic Reticulum

6.3K
Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
6.3K
Cohesins02:20

Cohesins

4.7K
Cohesin protein complexes are a molecular glue that holds two sister chromatids together. They play an important role both in mitosis and meiosis. In mitosis, all cohesin complexes present on the chromosomes are removed before the start of the anaphase stage.
Cohesin complexes in Meiotic Division
Meiosis involves two distinct rounds of chromosomal segregation and cell divisions— Meiosis I followed by Meiosis II – producing four daughter cells. Meiosis I includes the separation of...
4.7K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

69
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
69
Karyotyping01:17

Karyotyping

62.5K
Overview
62.5K
Alternative RNA Splicing02:18

Alternative RNA Splicing

21.8K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
21.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correlates of Elder Abuse in São Paulo, Brazil: The Roles of Age, Depression, and Religion.

Journal of religion and health·2026
Same author

Energies and new technologies in pelvic and pelvic floor dysfunctions.

Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia·2026
Same author

Elder abuse: prevalence estimates and associated factors from cross-sectional study in São Paulo, Brazil.

Journal of elder abuse & neglect·2025
Same author

Translation and Cultural Adaptation of the Creighton Model FertilityCare™ System Follow-up Form to Brazilian Portuguese.

Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia·2025
Same author

Voiding urodynamics parameters for women with and without symptomatic pelvic organ prolapse.

Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia·2025
Same author

Trospium Chloride in the Treatment of Overactive Bladder Syndrome and Detrusor Overactivity.

Advances in therapy·2025

Related Experiment Video

Updated: Sep 20, 2025

Laparoscopic Oocyte Retrieval and Cryopreservation during Vaginoplasty for Treatment of Mayer-Rokitansky-Kuster-Hauser Syndrome
11:53

Laparoscopic Oocyte Retrieval and Cryopreservation during Vaginoplasty for Treatment of Mayer-Rokitansky-Kuster-Hauser Syndrome

Published on: May 10, 2022

3.7K

Mayer-Rokitansky-Kuster-Hauser syndrome.

Claudia Cristina Takano Novoa1, Mila Torii Correa Leite1, Marair Gracio Ferreira Sartori1

  • 1Escola Paulista de Medicina Universidade Federal de São Paulo São PauloSP Brazil Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Revista Brasileira De Ginecologia E Obstetricia : Revista Da Federacao Brasileira Das Sociedades De Ginecologia E Obstetricia
|May 23, 2025
PubMed
Summary

Mayer-Rokitansky-Kuster-Hauser syndrome, a cause of vaginal agenesis, presents with primary amenorrhea and may involve urological/skeletal issues. Vaginal dilation is the primary successful treatment.

More Related Videos

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
06:48

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome

Published on: March 23, 2022

2.5K
Mutagenesis and Analysis of Genetic Mutations in the GC-rich KISS1 Receptor Sequence Identified in Humans with Reproductive Disorders
12:49

Mutagenesis and Analysis of Genetic Mutations in the GC-rich KISS1 Receptor Sequence Identified in Humans with Reproductive Disorders

Published on: September 4, 2011

14.1K

Related Experiment Videos

Last Updated: Sep 20, 2025

Laparoscopic Oocyte Retrieval and Cryopreservation during Vaginoplasty for Treatment of Mayer-Rokitansky-Kuster-Hauser Syndrome
11:53

Laparoscopic Oocyte Retrieval and Cryopreservation during Vaginoplasty for Treatment of Mayer-Rokitansky-Kuster-Hauser Syndrome

Published on: May 10, 2022

3.7K
Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
06:48

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome

Published on: March 23, 2022

2.5K
Mutagenesis and Analysis of Genetic Mutations in the GC-rich KISS1 Receptor Sequence Identified in Humans with Reproductive Disorders
12:49

Mutagenesis and Analysis of Genetic Mutations in the GC-rich KISS1 Receptor Sequence Identified in Humans with Reproductive Disorders

Published on: September 4, 2011

14.1K

Area of Science:

  • Reproductive Medicine
  • Pediatric Endocrinology
  • Genetics

Background:

  • Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH) is the primary cause of vaginal agenesis.
  • MRKH is characterized by primary amenorrhea, normal puberty, and potential co-occurring urological and skeletal anomalies.

Purpose of the Study:

  • To outline the diagnostic criteria and differential diagnoses for MRKH syndrome.
  • To emphasize the importance of laboratory and radiological investigations.
  • To highlight the primary treatment modality for vaginal agenesis in MRKH.

Main Methods:

  • Review of differential diagnoses including vaginal/uterine obstructions and disorders of sex development.
  • Description of necessary laboratory tests: testosterone, FSH, karyotype.
  • Description of radiological tests: pelvic ultrasound, MRI.

Main Results:

  • MRKH syndrome requires investigation for associated congenital conditions.
  • Differential diagnoses are crucial for accurate identification.
  • Vaginal dilation demonstrates high success rates as a first-line therapy.

Conclusions:

  • Accurate diagnosis of MRKH syndrome involves differentiating it from other conditions causing vaginal agenesis.
  • Comprehensive laboratory and imaging studies are essential for MRKH diagnosis.
  • Vaginal dilation is an effective initial treatment for MRKH-related vaginal agenesis.