[Synthesis of sesquiterpene metabolites in a Trichothecium roseum culture]

During the cultivation Trichothecium roseum forms biologically active sesquiterpenes in particular trichothecin and trichothecolon. The quantitative ratio of these compounds in cultural liquid changes depending on the cultivation conditions. The compounds taking part in terpenoids shant specifically increase the synthesis of sesquiterpenes in fungus culture. A possibility of intertransformation of different trichothecenes provides the stability of the fungus-producent to its toxical metabolites. A fermental system carrying out the transformation of trichothecin into trichotecolon has been revealed.