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Unraveling Ribonucleic Acid Unfolding: A Quantitative Comparison of Solution and Gas-Phase Unfolding

Anna G Anders1, Jacqueline Anthenien1, Ingrid R Kilde2

  • 1Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.

Analytical Chemistry
|May 23, 2025
PubMed
Summary

Collision-induced unfolding (CIU) advancements now quantitatively link gas-phase RNA structures to solution-phase data. This improved method, applied to MELAS-associated mt-tRNA, reveals strong correlations relevant to RNA

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