The potential applications of nanocomposites in 3D-printed drug delivery systems

Additive manufacturing is a renowned technology for producing three-dimensional objects, based on ceramic, metal, and plastic materials for different applications. This review examines and provides a perspective on using nanomaterials along with biopolymeric matrices for 3D printing (3DP) with potential applications in pharmaceutical dosage forms. Many 3DP methods have been developed for the formulation of drug delivery systems, including stereolithography, fused deposition modelling (FDM), selective laser sintering, and bioprinting through droplet- or extrusion-assisted techniques. Polymeric drug-loaded nanocapsules regulated the drug release profiles from 3D-printed tablets with faster drug release from 50% infill tablets. Also, incorporating nanomaterials/micro-ribbons significantly changed the mechanical and flow properties of polymers used in 3DP. For example, the addition of 1% w/w chitosan micro-ribbons to poly-vinyl alcohol powder improved filament mechanical properties for FDM 3DP in terms of flexibility and stiffness, with enhanced disintegration time of 3D-printed oral films. Berberine nanoparticles were integrated into a biodegradable and biocompatible 3D-printed pill, which facilitated sustained drug release and improved gastrointestinal absorption. Furthermore, nanocrystals enhanced the solubility of 3D-printed oral films. In conclusion, nanocomposites improved 3D-printed drug delivery systems in different aspects such as mechanical strength, solubility, and drug release profiles.